Esophagectomy is a difficult procedure that carries a high risk of morbidity and fatality. Complications can lengthen hospital stays and have a detrimental impact on the quality of life following surgery by affecting one's ability to swallow. Understanding the potential problems of this surgery is essential to prevent them. When doing an esophagectomy, the two most important guidelines are to try to avoid difficulties whenever feasible and to put measures in place to deal with them when they do arise. Reviewing both principles is the goal of this chapter
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