Hyperhidrosis and cardiovascular disorders are linked to sympathetic overactivity. To treat hyperhidrosis, endoscopic Thoracic sympathectomy (ETS) is used. We sought to examine the effects of ETS on cardiovascular outcomes and compare the risk for cardiovascular events across people with and without hyperhidrosis. With the aid of information obtained from the Korean Health Insurance Review and Assessment Service, we carried out a population-based cohort study across the country. Subjects who received a hyperhidrosis diagnosis for the first time in 2010 were selected and split into two groups based on whether or not they underwent ETS. A logistic regression model was used to determine propensity scores to compare hyperhidrosis patients with control volunteers. Stroke and ischemic heart disease were categorized as combined cardiovascular events.